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CURRENT
TREATMENT

LANDSCAPE

IN ADVANCED HEPATOCELLULAR CARCINOMA (HCC)

Explore the evolution of the advanced HCC treatment landscape, current guidelines, and insights to apply to your clinical practice.

NAVIGATING THE EVOLVING TREATMENT LANDSCAPE IN ADVANCED HCC

mOS of standard of care (SoC) treatment classes for advanced HCC over time

Chart showing mOS of standard of care treatment classes for advanced HCC over time

CLINICAL GUIDELINES

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Review the NCCN Guidelines1

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Review the AASLD guidelines15

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Review the BCLC guidelines16

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Review the ASCO guidelines17

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Treatment decision making in advanced HCC requires a multidisciplinary approach and consideration of several factors.

Let Lorem Ipsum be your compass in navigating the complexities and latest developments in HCC patient care.

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Abbreviations:
AASLD=American Association for the Study of Liver Diseases; ASCO=American Society of Clinical Oncology; BCLC=Barcelona Clinic Liver Cancer;
HCC=hepatocellular carcinoma; IO=immunotherapy; mOS=median overall survival; NCCN=National Comprehensive Cancer Network; SoC=standard of care; TKI=tyrosine kinase inhibitor.
References:
1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Hepatocellular Carcinoma V.1.2025. © National Comprehensive Cancer Network, Inc. 2025. All rights reserved. Accessed September 30, 2025. To view the most recent and complete version of the guideline, go online to NCCN.org; 2. Llovet JM, et al. Sorafenib in Advanced Hepatocellular Carcinoma. N Engl J Med. 2008;359(4):378–390; 3. Cidon EU. Systemic treatment of hepatocellular carcinoma: Past, present and future. World J Hepatol. 2017;9(18):797–807; 4. Lai CL, et al. Doxorubicin Versus No Antitumor Therapy in Inoperable Hepatocellular Carcinoma. A prospective randomized trial. Cancer. 1988;62(3):479–483; 5. Liu J, et al. Small molecule tyrosine kinase inhibitors approved for systemic therapy of advanced hepatocellular carcinoma: recent advances and future perspectives. Discov Oncol. 2024;15(1):259; 6. Kudo M. Management of Hepatocellular Carcinoma in Japan as a World-Leading Model. Liver Cancer. 2018;7(2):134–147; 7. Alqahtani SA and Colombo MG. Current status of first-line therapy, anti-angiogenic therapy and its combinations of other agents for unresectable hepatocellular carcinoma. World J Gastrointest Oncol. 2021;13(12):2038–2049; 8. Zhang H, et al. Recent advances in systemic therapy for hepatocellular carcinoma. Biomark Res. 2022;10(1):3; 9. Lazzaro A and Hartshorn KL. A Comprehensive Narrative Review on the History, Current Landscape, and Future Directions of Hepatocellular Carcinoma (HCC) Systemic Therapy. Cancers (Basel). 2023;15(9):2506; 10. Patel TH, et al. FDA Approval Summary: Tremelimumab in combination with durvalumab for the treatment of patients with unresectable hepatocellular carcinoma. Clin Cancer Res. 2024;30(2):269–273; 11. Yau T, et al. Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib: The CheckMate 040 Randomized Clinical Trial. JAMA Oncol. 2020;6(11):e204564; 11. Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib. JAMA Oncol. 2020;6(11):e204564. 12. Melero I, et al. Nivolumab plus ipilimumab combination therapy in patients with advanced hepatocellular carcinoma previously treated with sorafenib: 5-year results from CheckMate 040. Ann Oncol. 2024;35(6):537–548; 13. Rimassa L, et al. Five-year overall survival update from the HIMALAYA study of tremelimumab plus durvalumab in unresectable HCC. J Hepatol. 2025;83(4):899–908; 14. Yau T, et al. Nivolumab plus ipilimumab versus lenvatinib or sorafenib as first-line treatment for unresectable hepatocellular carcinoma (CheckMate 9DW): an open-label, randomised, phase 3 trial. Lancet. 2025;405(10492):1851–1864; 15. Singal AG, et al. AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology. 2023;78(6):1922–1965; 16. Reig M, et al. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol. 2022;76(3):681–693; 17. Gordan JD, et al. Systemic Therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline Update. J Clin Oncol. 2024;42(15):1830–1850.